Penn Senator 6/0 with a broom stick type rod - pick a brand. you want lots of drag in the reel and you get that with the Senator but still have a decent retrieve ratio -
That's my preference for grouper digging (until I started freestyle jigging anyway) Other brands are fine though.
Here's what you look for:
Reel - 30 pounds of drag or more - you'll need the drag to get that big grouper off the bottom before he can run into a hole. I lock the drag down when grouper fishing. They usually don't have far to go to get in a hole - they get in a hole - GAME OVER.
Rod - stiff (versus fast action) - don't need movement in the rod, rather you want to jerk up the rod and not have much flex - see above about hole.
Line: Braid is best for grouper fishing as it has little to no stretch. If this is for grouper fishing (not trolling) You don't need 500 yards of braid. Take whatever depth you plan to fish times x 3 then put the rest on in mono. So if you figure 200 feet of water is the deepest you plan to fish (that would be over 40 miles out around here, Al) then 200 yards of Braid is enough but put mono behind it so the braid is out close to the outer part of the spool to get the highest retrieve ratio. Braid is over 20 cents a yard when you get to the 50/65 pound class so save yourself some money.