There are definitely some big blue cats there. Try around March/April during the shad run up the river to the dam. The cats will sit under the large schools waiting for a meal.
If you are fishing from a boat, don't use a good anchor as there is a lot of junk on the bottom and you will probably get snagged. Lots of guys use a cinder block with a section of heavy duty mono between the block and the main line. that way if the cinder clock gets hung it will break off and you aren't out an anchor.